Search for: All records

Abstract The one-dimensional quantum breakdown model, which features spatially asymmetric fermionic interactions simulating the electrical breakdown phenomenon, exhibits an exponential U(1) symmetry and a variety of dynamical phases including many-body localization and quantum chaos with quantum scar states. We investigate the minimal quantum breakdown model with the minimal number of on-site fermion orbitals required for the interaction and identify a large number of local conserved charges in the model. We then reveal a mapping between the minimal quantum breakdown model in certain charge sectors and a quantum link model which simulates theU(1) lattice gauge theory and show that the local conserved charges map to the gauge symmetry generators. A special charge sector of the model further maps to the PXP model, which shows quantum many-body scars. This mapping unveils the rich dynamics in different Krylov subspaces characterized by different gauge configurations in the quantum breakdown model. 

Abstract During progression from carcinoma in situ to an invasive tumor, the immune system is engaged in complex sets of interactions with various tumor cells. Tumor cell plasticity alters disease trajectories via epithelial-to-mesenchymal transition (EMT). Several of the same pathways that regulate EMT are involved in tumor-immune interactions, yet little is known about the mechanisms and consequences of crosstalk between these regulatory processes. Here we introduce a multiscale evolutionary model to describe tumor-immune-EMT interactions and their impact on epithelial cancer progression from in situ to invasive disease. Through simulation of patient cohorts in silico, the model predicts that a controllable region maximizes invasion-free survival. This controllable region depends on properties of the mesenchymal tumor cell phenotype: its growth rate and its immune-evasiveness. In light of the model predictions, we analyze EMT-inflammation-associated data from The Cancer Genome Atlas, and find that association with EMT worsens invasion-free survival probabilities. This result supports the predictions of the model, and leads to the identification of genes that influence outcomes in bladder and uterine cancer, including FGF pathway members. These results suggest new means to delay disease progression, and demonstrate the importance of studying cancer-immune interactions in light of EMT. 

The standard model of cosmology has provided a good phenomenological description of a wide range of observations both at astrophysical and cosmological scales for several decades. This concordance model is constructed by a universal cosmological constant and supported by a matter sector described by the standard model of particle physics and a cold dark matter contribution, as well as very early-time inflationary physics, and underpinned by gravitation through general relativity. There have always been open questions about the soundness of the foundations of the standard model. However, recent years have shown that there may also be questions from the observational sector with the emergence of differences between certain cosmological probes. In this White Paper, we identify the key objectives that need to be addressed over the coming decade together with the core science projects that aim to meet these challenges. These discordances primarily rest on the divergence in the measurement of core cosmological parameters with varying levels of statistical confidence. These possible statistical tensions may be partially accounted for by systematics in various measurements or cosmological probes but there is also a growing indication of potential new physics beyond the standard model. After reviewing the principal probes used in the measurement of cosmological parameters, as well as potential systematics, we discuss the most promising array of potential new physics that may be observable in upcoming surveys. We also discuss the growing set of novel data analysis approaches that go beyond traditional methods to test physical models. These new methods will become increasingly important in the coming years as the volume of survey data continues to increase, and as the degeneracy between predictions of different physical models grows. There are several perspectives on the divergences between the values of cosmological parameters, such as the model-independent probes in the late Universe and model-dependent measurements in the early Universe, which we cover at length. The White Paper closes with a number of recommendations for the community to focus on for the upcoming decade of observational cosmology, statistical data analysis, and fundamental physics developments 

Encapsulation of ionic nanoparticles in a hydrogel microparticle, i.e. microgel, produces a target-stimulated probe for molecular detection. Selective reactive oxygen species (ROS) triggers the release of cations from the microgel which subsequently turn on the fluorogenic dyes to emit intense fluorescence, permiting rapid detection of ROS or ROS-producing molecules. The ROS-responsive microgel provides the advantages of simple fabrication, bright and stable signals, easy handling, and rapid response, carrying high promises in biomedical applications.